Lazio got revenge on AC Milan after Saturday`s Serie A defeat, knocking last year`s finalists out of the Coppa Italia and setting up a quarter-final clash against Bologna.

These teams met again just a few days after a fiery and controversial Serie A game at San Siro on Saturday, which the Rossoneri won 1-0 with a late penalty appeal rejected. Youssouf Fofana, Santiago Gimenez and Zachary Athekame didn`t make the trip, but Ardon Jashari got his first start for the club after fracturing his fibula in August. The Aquile were still missing Danilo Cataldi, Nicolò Rovella and Samuel Gigot, but Taty Castellanos had his first start since October 4.

ROME, ITALY - DECEMBER 04: Pervis Estupinan of AC Milan battles for possession with Gustav Isaksen of Lazio during the Coppa Italia Round of 16 match between SS Lazio and AC Milan at Olimpico Stadium on December 04, 2025 in Rome, Italy. (Photo by Paolo Bruno/Getty Images)

Strahinja Pavlovic was booked in the first 90 seconds after Pervis Estupinan was robbed by Gustav Isaksen, while Toma Basic sprinted forward on a Mattia Zaccagni flick and flashed his angled drive inches wide of the far post.

Castellanos failed to make the most of a poor Alexis Saelemaekers back-pass, scuffing the finish into the arms of Mike Maignan, while on the stroke of half-time Maignan made a reaction save on Isaksen`s volley from a deflected corner.

Luca Pellegrini spotted Maignan off his line and floated a lob over the empty net, but Milan finally created a genuine scoring opportunity with Ruben Loftus-Cheek nodding an Estupinan cross just over the bar.

ROME, ITALY - DECEMBER 04: Adrien Rabiot of AC Milan is challenged by Matteo Guendouzi of Lazio during the Coppa Italia Round of 16 match between SS Lazio and AC Milan at Olimpico Stadium on December 04, 2025 in Rome, Italy. (Photo by Paolo Bruno/Getty Images)

The Rossoneri were more aggressive in the second half and Saelemaekers saw his curler plucked out of the air by Christos Mandas, but Koni De Winter had to prevent Tijjani Noslin meeting the Zaccagni cross from six yards.

Loftus-Cheek turned another header off target at the back post on Adrien Rabiot`s cross, but Milan wasted a huge opportunity when Jashari floated a ball to the by-line for Estupinan to knock back, Rafael Leao ballooning over from eight yards.

ROME, ITALY - DECEMBER 04: Toma Basic of Lazio passes the ball whilst under pressure from Alexis Saelemaekers of AC Milan during the Coppa Italia Round of 16 match between SS Lazio and AC Milan at Olimpico Stadium on December 04, 2025 in Rome, Italy. (Photo by Paolo Bruno/Getty Images)

Tijjani Noslin slightly over-hit the return pass for Zaccagni and Milan protested that a corner was awarded when it might`ve hit Alessio Romagnoli last. It was on that set play that Lazio broke the deadlock, Zaccagni peeling away from his marker for a free header at the near post on the Nuno Tavares corner.

Maignan kept the tie alive with another big reaction save to deny Noslin from close range after a free kick ricocheted around in the box.

In stoppages, Mandas flew to palm away a Christian Pulisic scuffed strike from just inside the box on Davide Bartesaghi`s cross.